July 2, 2019

Patented technology applied in SynGEM, a needle-free nasal spray vaccine against respiratory syncytial virus

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Re-Issuance of U.S. Patent No. RE 47,471 further bolsters Mucosis’ intellectual property portfolio

Groningen / Odijk, The Netherlands, July 2, 2019 –  The trustee of biotech company Mucosis B.V., Mr. Holtz LLM and Virtuvax B.V. today announce that the US Patent Office (USPTO) has issued patent RE.  47,471 dated July 2, 2019. The patent is a reissue of Mucosis’ US Patent No. 9,060,975 (“reset patent”). The granted patent contains twenty-five claims including thirteen original as well as modified claims of the reset patent plus twelve additi...

April 5, 2019

#ReSViNET , the Respiratory Syncytial Virus Network, selected the recent publication in AJRCCM on the SynGEM Phase I clinical trial as paper of the month March. The study which was executed by Imperial College London, showed that #SynGEM is safe and capable of inducing long term immune responses. A commentary published in the same journal suggested to test the vaccine in a human challenge study. The author manuscript can now be downloaded free of charge from the ReSViNET website

March 6, 2019

SynGEM a needle-free nasal spray vaccine against respiratory syncytial virus

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SynGEM shown to be safe and immunogenic in healthy adults

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SynGEM the first non-replicating intranasal RSV subunit vaccine to induce persistent antibody responses in humans

Groningen, the Netherlands, March 6, 2019 – Virtuvax B.V. and the trustee of biotech company Mucosis B.V., Mr. Holtz LLM today announce the results of a first-in-human study of the intranasal Respiratory Syncytial Virus (RSV) vaccine candidate, SynGEM. The study was executed by Imperial College London. Results of the study have been posted (in press) on the website of the American Journal of...

February 27, 2019

A new publication in the American Journal of Respiratory and Critical Care Medicine, headed by senior author prof. Louis Bont of UMC Utrecht makes a plea to consider further development of the SynGEM vaccine. Commenting on the results of the SynGEM RSV clinical trial, the authors indicate that the fail-fast approach that has been adopted by pharmaceutical industry, makes a challenging endeavor for development of RSV vaccines. Applying the fail-fast approach, the SynGEM vaccine was evaluated based on early results, generated until 56 days after start of the clinical trial. These early results were found inconclusive and consequently funding of Mu...

February 13, 2019

Today phase I clinical trial data of the Mucosis intranasal RSV F protein vaccine were published on-line. The vaccine was shown to be safe and immunogenic and was shown to induce long-lasting anti-RSV antibodies in healthy adults despite high pre-existing antibody levels. The study was designed as a phase I, randomised, double-blind, placebo-controlled trial in 48 healthy volunteers aged 18-49 year and was executed by Imperial College London. Results were published in the high rated journal AJRCCM. 

The vaccine was developed by Mucosis (NL) and incorporates an RSV-F protein with mutations to maint...

September 19, 2018

Virtuvax consults in vaccine development and provides biosimilar and vaccine technologies. A most recent one, is the prefusion RSV-F vaccine technology. If you are interested, I would be most interested to meet you at the developing countries vaccine manufacturers network (DCVMN) annual meeting in Kunming, China, from October 29 - 31 2018.

Tags: vaccine development, disruptive technology, biosimilar, monoclonal antibody, vaccine technology, DCVMN, Kunming, vaccine consultancy, RSV, pre-fusion RSV-F, RSV vaccine, pneumococcal vaccine

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