A new publication in the American Journal of Respiratory and Critical Care Medicine, headed by senior author prof. Louis Bont of UMC Utrecht makes a plea to consider further development of the SynGEM vaccine. Commenting on the results of the SynGEM RSV clinical trial, the authors indicate that the fail-fast approach that has been adopted by pharmaceutical industry, makes a challenging endeavor for development of RSV vaccines. Applying the fail-fast approach, the SynGEM vaccin

Today phase I clinical trial data of the Mucosis intranasal RSV F protein vaccine were published on-line. The vaccine was shown to be safe and immunogenic and was shown to induce long-lasting anti-RSV antibodies in healthy adults despite high pre-existing antibody levels. The study was designed as a phase I, randomised, double-blind, placebo-controlled trial in 48 healthy volunteers aged 18-49 year and was executed by Imperial College London. Results were published in the hig