New comment by UMC Utrecht on the SynGEM vaccine trial is a plea to consider the vaccine in an RSV c
- Ernst Soethout, MD
- 27 feb 2019
- 1 minuten om te lezen

A new publication in the American Journal of Respiratory and Critical Care Medicine, headed by senior author prof. Louis Bont of UMC Utrecht makes a plea to consider further development of the SynGEM vaccine. Commenting on the results of the SynGEM RSV clinical trial, the authors indicate that the fail-fast approach that has been adopted by pharmaceutical industry, makes a challenging endeavor for development of RSV vaccines. Applying the fail-fast approach, the SynGEM vaccine was evaluated based on early results, generated until 56 days after start of the clinical trial. These early results were found inconclusive and consequently funding of Mucosis which was sponsor of the clinical trial and owner of the vaccine, was discontinued. The early clinical trial data were however far from complete as long-term immune responses and cellular immunogenicity data were not known when the decision was taken to discontinue funding. The final results of the clinical trial eventually did show such long-term immune responses.
The authors of the commenting paper reveal that in the absence of serological markers of protection to RSV, it is difficult to determine that a vaccine is protective. As indicated by the authors: 'we are left with a trial-and-error approach'.
The authors suggest that testing of the vaccine in a human challenge model may be a quick way to finally determine proof of concept of efficacy.
The SynGEM RSV vaccine technology is now being made available by Virtuvax on behalf of the Trustee, Mr Holtz LLM.
aceh4d
aceh4d
aceh4d
tus4d
tus4d
jmkbet
neototo
toto slot
Binggung Kalah terus ? Cobain deh ..
slot toto
slot toto
toto slot
aceh4d
aceh4d
aceh4d
Live draw hongkong
Toto slot
Slot toto
Slot online
Slot gacor
Toto gacor
Slot togel
Toto togel
Slot demo
tus4d
aceh4d
aceh4d
aceh4d
aceh4d
aceh4d
aceh4d
aceh4d
aceh4d
aceh4d
slot gacor
slot gacor
slot gacor
slot toto
slot toto
slot toto
slot toto
slot toto
slot toto
slot toto
slot toto
slot toto
slot toto
scatter hitam
scatter hitam
scatter hitam
scatter hitam
scatter hitam
scatter hitam
rtp aceh4d
bandar togel
terminal4d
link terminal4d
daftar terminal4d
situs slot gacor
toto slot
toto4d gacor
rtp gacor
slot toto gacor
link slot gacor
situs togel
agen togel resmi
agen slot resmi
agen toto 4d
situs gacor
pola gacor